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Researchers at Harvard Medical School in the US have discovered a gene mutation that slows the metabolism of sugar in the gut, giving people who have the mutation a distinct advantage over those who do not.

美国哈佛大学医学院的研究人员发现，某种基因突变可以减缓肠道中糖的新陈代谢。因此有这一基因突变的人比没有的人有明显的优势。

Those with the mutation have a lower risk of diabetes,obesity, heart failure, and even death. The researchers say their finding could provide the basis for drug therapies that could mimic the workings of this gene mutation, offering a potential benefit for the millions of people who suffer with diabetes, heart disease, and obesity.

有这种基因突变的人患上糖尿病、肥胖症、心脏衰竭甚至死亡的风险偏低。研究人员称，他们的发现可以为能够模仿这种基因突变工作原理的药物疗法提供依据，这为数百万糖尿病、心脏病和肥胖症患者提供了潜在的福利。

The study, which has been published in the Journal of the American College of Cardiology, shows that people who have the natural gene mutation have an advantage when it comes to diet. Those who eat a high-carbohydrate diet and have this mutation will absorb less glucose than those without the mutation. Ahigh-carbohydrate diet includes such foods as pasta, breads, cookies, and sugar-sweetened beverages.

该项研究公布在《美国心脏病学会杂志》上。研究表明，有这种基因突变的人在饮食方面有优势。与没有这种基因突变的人相比，吃高碳水化合物食物的人如果有这种基因突变，吸收的葡萄糖就比较少。高碳水化合物饮食包括面食、饼干和含糖饮料。

Scott Solomon, who led the research, said: ‘We’re excited about this study because it helps clarify the link between what we eat, what we absorb, and our risk for disease. Knowing this opens the door to improved therapies for cardiometabolic disease.’

负责该项研究的斯科特•所罗门说：“我们对这项研究感到很兴奋，因为它澄清了我们吃什么、吸收什么和可能会患上什么病之间的关系。知道了这一点就为我们改进心血管疾病的疗法打开了一扇门。”

During the study, the researchers analysed the relationship between SGLT-1 mutations and cardiometabolic disease using genetic data obtained from 8,478 participants in the Atherosclerosis Risk In Communities (ARIC) study.

研究期间，研究人员借助社区动脉粥样硬化风险研究中8478名参与者的基因数据，分析了SGLT-1（一种蛋白）突变与心血管代谢疾病之间的关系。

The researchers found that about 6 per cent of the subjects carried a mutation in SGLT-1 that causes limited impairment of glucose absorption. Individuals with this mutation had a lower incidence of type 2diabetes, were less obese, had a lower incidence of heart failure, and had a lower mortality rate when compared to those without the mutation, even after adjusting for dietary intake.

研究人员发现，研究对象中有6%携有SGLT-1基因突变，这种基因突变对葡萄糖吸收造成了有限的损害。与没有这种基因突变的人相比，即便对膳食摄入进行了调整，有这种基因突变的人2型糖尿病、肥胖症和心脏衰竭的发病率要偏低，死亡率也偏低、

Based on these findings, the scientists suggest that selectively blocking the SGLT-1 receptor could provide a way to slow down glucose uptake to prevent or treat cardiometabolic disease and its consequences.

基于这些发现，科学家暗示，选择性封阻SGLT-1感受器是减少葡萄糖摄入量的一种方式，可以预防或治疗心血管代谢疾病及其后果。

来源：旁观者

编译：清木

词汇积累
 

Gene mutation 基因突变
Cardiology 心脏病学
Incidence 发病率
Consequences 后果，影响